Frontline: Characterization of BT3 molecules belonging to the B7 family expressed on immune cells
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چکیده
منابع مشابه
Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells
B7-DC molecules are known to function as ligands on antigen-presenting cells (APCs), enhancing T cell activation. In this study, cross-linking B7-DC with the monoclonal antibody sHIgM12 directly potentiates dendritic cell (DC) function by enhancing DC presentation of major histocompatibility complex-peptide complexes, promoting DC survival; and increasing secretion of interleukin (IL)-12p70, a ...
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The B7 family consists of structurally related, cell-surface proteins that regulate immune responses by delivering costimulatory or coinhibitory signals through their ligands. Eight family members have been identified to date including CD80 (B7-1), CD86 (B7-2), CD274 (programmed cell death-1 ligand [PD-L1]), CD273 (programmed cell death-2 ligand [PD-L2]), CD275 (inducible costimulator ligand [I...
متن کاملCharacterization of Amino Acid Transporters Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38
Hellsten, S. V. 2016. Characterization of Amino Acid Transporters. Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1180. 43 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9477-3. In cells and organelles transporters are responsible for translocat...
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The B7-CD28 family of ligands and receptors play important roles in T-cell co-stimulation and co-inhibition. Phylogenetically they can be divided into three groups. The recent discovery of the new molecules (B7-H3 [CD276], B7x [B7-H4/B7S1], and HHLA2 [B7H7/B7-H5]/TMIGD2 [IGPR-1/CD28H]) of the group III has expanded therapeutic possibilities for the treatment of human diseases. In this review, w...
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Whereas B7-1/B7-2 and CD28/cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) serve as the main switches regulating the clonal composition of activated naive T cells, other B7 family members fine-tune the expansion and properties of activated T cells. Inducible costimulatory molecule (ICOS)-B7h promotes T-dependent antibody isotype switching and expansion of effector cells. Effector T cells t...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2004
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200425227